Abnormal sodium channel distribution in optic nerve axons in a model of in ̄ammatory demyelination
نویسندگان
چکیده
Department of Neurology and PVA/EPVA Center for Neuroscience Research, Yale University School of Medicine, New Haven and Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT, USA Correspondence to: Stephen G. Waxman, MD, PhD, Department of Neurology LCI 707, Yale University School of Medicine, 333 Cedar Street, PO Box 208018, New Haven, CT 06520-8018, USA E-mail: [email protected]
منابع مشابه
Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination.
Myelinated fibres are characterized by the aggregation of Nav1.6 sodium channels within the axon membrane at nodes of Ranvier, where their presence supports saltatory conduction. In this study, we used immunocytochemical methods to study the organization of sodium channels along axons in experimental allergic encephalomyelitis (EAE), a model of multiple sclerosis. We studied axons within the op...
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